POTENSI TANAMAN SAMBUNG NYAWA (Gynura procumbens) SEBAGAI ANTIHIPERURISEMIA BERDASARKAN KANDUNGAN ZAT AKTIFNYA: LITERATURE REVIEW ARTICLE

Authors

  • Himyatul - Hidayah Universitas Buana Perjuangan Karawang
  • Neni Sri Gunarti Universitas Buana Perjuangan Karawang
  • Hardiyanti Pajri Rizki Universitas Buana Perjuangan Karawang
  • Surya Amal Universitas Buana Perjuangan Karawang

DOI:

https://doi.org/10.52434/jfb.v14i1.1344

Keywords:

Antihiperurisemia, Gynura procumbens, metabolit sekunder

Abstract

Hiperurisemia merupakan suatu kondisi di mana terjadi peningkatan produksi kadar asam urat di dalam tubuh. Penggunaan obat antihiperurisemia dapat menimbulkan efek samping, sehingga penggunaan obat tradisional dengan bahan alam dapat digunakan sebagai alternatif pengobatan. Oleh karena itu, diperlukan pengembangan senyawa dengan aktivitas penghambat xantin oksidase yang berasal dari tumbuhan alam dengan efek samping yang lebih rendah. Salah satunya yaitu menggunakan daun Sambung Nyawa (Gynura procumbens) sebagai antihiperurisemia. Literature review article ini bertujuan untuk mengetahui kandungan senyawa aktif Sambung Nyawa yang digunakan sebagai antihiperurisemia dengan mengkaji beberapa literatur yang berkaitan dengan hal tersebut. Pencarian literatur yang akan digunakan hanya terbatas pada senyawa aktif Sambung Nyawa sebagai antihiperurisemia yang dipublikasikan pada tahun 2011-2021. Proses pencarian dilakukan menggunakan Google Scholar, PubMed dam ScienceDirect dengan kata kunci “Gynura procumbens, antihiperurisemia, sambung nyawa, xantin oksidase, Activity flavonoid of antihyperuricemic†dan  “Mechanism of flavonoids as antihyperuricemiaâ€. Hasil akhir pencarian tersebut didapatkan 7 artikel yang digunakan. Berdasarkan literature review yang telah dilakukan menunjukkan bahwa golongan flavonoid dengan kandungan senyawa aktif kuersetin, kaempferol, apigenin, myricetin dan rutin dari Sambung Nyawa yang paling banyak memiliki kemampuan sebagai antihiperurisemia yang ditandai dengan penghambatan xanthine oxidase.

Author Biography

Himyatul - Hidayah, Universitas Buana Perjuangan Karawang

Fakultas Farmasi dan Asisten Ahli

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Published

2023-01-31

Issue

Vol. 14 No. 1 (2023): Jurnal Ilmiah Farmako Bahari

Section

Review Article

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