EVALUASI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL HERBA SURUHAN (PEPEROMIA PELLUCIDA L.), HERBA SELEDRI (APIUM GRAVEOLENS L.) DAN KOMBINASI EKSTRAK: STUDI IN VIVO BERBASIS BUKTI ILMIAH

Yogi Rahman Nugraha, Dani Sujana, Yunahara Farida, Faizatun Faizatun

Abstract


Hiperurisemia adalah suatu kondisi dimana kadar asam urat meningkat. Hiperurisemia disebabkan oleh kelainan genetik pada sistem metabolisme tubuh yang mencegah tubuh mengeluarkan asam urat dari tubuh. Flavonoid dan alkaloid merupakan senyawa yang dipercaya mampu menurunkan kadar asam urat dalam darah dengan cara menghambat kerja xantin oksidase dan superoksidase. Herba suruhan dan seledri telah lama dipakai sebagai obat tradisional untuk mengatasi keluhan asam urat. Pada penelitian ini dilaporkan bahwa ekstrak etanol seledri dan herba seledri serta ekstrak gabungan menunjukkan aktivitas antihiperurisemia yang signifikan terhadap kontrol negatif selama pengamatan (p<0,05). Dosis 250 mg/kgBB menunjukkan aktivitas paling baik (kombinasi ekstrak etanol herba suruhan (Peperomia pellucida 75%) ekstrak etanol herba seledri (Apium graveolens 25%) dengan penurunan asam urat sebesar 58,4%.


Keywords


antihiperurisemia, herba seledri, herba suruhan, kombinasi ekstrak

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DOI: http://dx.doi.org/10.52434/jfb.v13i1.1312

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