FUCOIDAN NANOENCAPSULATION FROM BROWN ALGAE (Sargassum polycystum) AS A POTENTIAL MARINE IMMUNOMODULATORY AGENT

Penulis

  • Ungsari Rizki Eka Purwanto Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi
  • Endang Diyah Ikasari Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi
  • I Kadek Bagiana Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi
  • Lia Kusmita Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi
  • Ni Nyoman Ayu Indah Trisnayanthi Indonesian Marine Education and Research Organization Department of Chemistry, Universitas Pendidikan Ganesha Singaraja
  • I Wayan Mudianta Indonesian Marine Education and Research Organization Department of Chemistry, Universitas Pendidikan Ganesha Singaraja
  • Rahmadi Prasetijo Indonesian Marine Education and Research Organization Department of Chemistry, Universitas Pendidikan Ganesha Singaraja

DOI:

https://doi.org/10.52434/jifb.v15i1.3207

Kata Kunci:

fucoidan, brown_algae, nanoencapsulation, immunomodulator

Abstrak

The quest for better and more effective treatments has encouraged the search for therapies derived from natural sources to obtain effective immune therapy, considering that several pandemics have arisen caused by viruses. Developing fucoidan from brown algae in drug encapsulation as an immunomodulator could be more promising. This study aimed to produce nanoencapsulation loaded with fucoidan-purified extract from brown algae and to evaluate the influence of nanoencapsulation formulation on the immunomodulatory activity of fucoidan. Fucoidan was obtained from brown algae and extracted by hot aqueous, followed by ethanol purification. Nanoencapsulation of fucoidan purified extract was prepared using the ionic gelation method. The carbon clearance method was carried out for the immunomodulatory activity test of the nanoencapsulation of fucoidan purified extract. Nanoencapsulation of fucoidan purified extract with the optimum composition of maltodextrin 9.9% and S-TPP 0.1% (1:5) resulted in particle size of 715.4 nm, zeta potential -0.1 mV, pH 7.54, transmittance 97.54%+0.08, and entrapment efficiency 89.94%+0.17. The carbon clearance test showed that the nanoencapsulation of fucoidan was a strong immunostimulant with a phagocytosis index of 1.65. The development of nanoencapsulation could increase the phagocytosis index of fucoidan purified extracts from brown algae. Further molecular studies are needed to demonstrate the molecular activity of this preparation as an immunomodulator.

Biografi Penulis

Endang Diyah Ikasari, Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi

teknologi farmasi

Referensi

Hertanto DM, Wiratama BS, Sutanto H, Wungu CDK. Immunomodulation as a potent COVID-19 pharmacotherapy: past, present and future. J Inflamm Res [Internet]. 2021;14:3419–28. Available from: https://www.dovepress.com/immunomodulation-as-a-potent-covid-19-pharmacotherapy-past-present-and-peer-reviewed-fulltext-article-JIR

Catanzaro M, Corsini E, Rosini M, Racchi M, Lanni C. Immunomodulators inspired by nature: a review on. Molecules. 2018;23(11):1–17.

Li Q, Wang X, Wan Y, Hu X, Liu J, Wang J. In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice. J Funct Foods [Internet]. 2023;103:1–8. Available from: https://www.sciencedirect.com/science/article/pii/S1756464623000865

Yang J, Yang X, Pan W, Wang M, Lu Y, Zhang J, et al. Fucoidan-supplemented diet potentiates immune checkpoint blockage by enhancing anti-tumor immunity. Front Cell Dev Biol [Internet]. 2021;9:1–16. Available from: https://pubmed.ncbi.nlm.nih.gov/34434936/

Kwon PS, Oh H, Kwon SJ, Jin W, Zhang F, Fraser K, et al. Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro. Cell Discov [Internet]. 2020;6(1):1–4. Available from: https://www.nature.com/articles/s41421-020-00192-8

Unduhan

File Tambahan

Diterbitkan

2024-01-31

Terbitan

Vol 15 No 1 (2024): Jurnal Ilmiah Farmako Bahari

Bagian

Research Article

Lisensi

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