KO-KRISTAL: NIKOTINAMID SEBAGAI KOFORMER

Authors

  • Hairunnisa Hairunnisa Departemen Farmasetika dan Teknologi Farmasi, Fakultas Farmasi Universitas Padjadjaran Akademi Farmasi YARSI
  • Iyan Sopyan Departemen Farmasetika dan Teknologi Farmasi, Fakultas Farmasi Universitas Padjadjaran
  • Dolih Gozali Departemen Farmasetika dan Teknologi Farmasi, Fakultas Farmasi Universitas Padjadjaran

DOI:

https://doi.org/10.52434/jfb.v10i2.652

Abstract

Kokristal merupakan cara alternatif yang dapat dilakukan untuk meningkatkan kemampuan melarut obat yang sukar larut dalam air dan meningkatkan bioavailabilitas obat yang buruk. Ada berbagai teknik yang dapat dilakukan dalam pembuatan kokristal seperti Hot Melt Extrusion, solvent evaporation, solvent drop grinding, slurry. Nikotinamid telah banyak digunakan sebagai koformer dalam pembentukan ko-kristal. Berdasarkan struktur kimianya, nikotinamid memiliki peluang besar untuk membentuk ko-kristal dengan berbagai macam bahan aktif farmasi. Modifikasi kokristal bahan aktif farmasi juga dapat maningkatkan laju disolusi dari bahan aktif farmasi itu sendiri dibandingkan kecepatan disolusi bahan aktif farmasi murninya Kata kunci: kokristal, nikotinamid, disolusi

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Published

2019-11-14

Issue

Vol. 10 No. 2 (2019): Jurnal Ilmiah Farmako Bahari

Section

Research Article

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