REVIEW OF THE PHYTOTHERAPY FOR NEPHROLITHIASIS

Hanna Salwa Ridwan, Sandra Megantara, Jutti Levita

Abstract


Nephrolithiasis (kidney stone) cases have a prevalence ranging from 1% to 13%. The disease not only hampers kidney function but also elevates the risk of chronic kidney diseases. The pathophysiology of nephrolithiasis is closely linked to elevated concentrations of calcium, oxalate, and/or uric acid in the urine. Pharmacotherapy to manage nephrolithiasis includes thiazide diuretics, allopurinol, citrate supplements, and alpha-blockers that have been prescribed to relieve symptoms. In addition, there is growing interest in exploring the potential of phytotherapy. This review aims to identify suitable phytotherapy approaches by examining relevant articles on nephrolithiasis. The research methodology involved searching PubMed articles using the keywords of (("Plant Extracts") AND ("Nephrolithiasis")) OR ("Ureterolithiasis"). The articles obtained from the initial search were n =123. 2 authors screened articles for their eligibility. The inclusion criteria were limited to articles written in English, topics related to nephrolithiasis and not other kidney diseases, the botanical names of the plants and the method of extraction are clearly described, complete studies with clear descriptions regarding the methods and results, not synthetic drugs, and not involving medical instruments or laser to remove the stones. Articles included in the review were n = 17. Water and hydro-alcohol were the solvents used to extract the plants. Twenty-two plants have confirmed their anti-nephrolithiasis activity, and nine articles described the assay by in vivo study, two by in vitro study, three by both in vitro and in vivo study, and only one article mentioned a study in humans by a randomized-control trial on a mixture of herbs. It is concluded that Rhizoma alismatis, Poria cocos, Polyporus umbellatus, Atractylodis macrocephalae, and Cinnamomi Cassiae prepared as a mixture in the Wu-Ling-San formula have a potential therapeutic effect on nephrolithiasis, as this formula has been studied in humans.


Keywords


nephrolithiasis; phytotherapy; plants

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References


Chen W, Liu WR, Hou JB, Ding JR, Peng ZJ, Gao SY, Dong X, Ma JH, Lin QS, Lu JR, Guo ZY. Metabolomic analysis reveals a protective effect of Fu-Fang-Jin- Qian-Chao herbal granules on oxalate-induced kidney injury. Biosci Rep. 2019;39(2):BSR20181833. DOI: 10.1042/BSR20181833

Mehrabi S, Askarpour E, Mehrabi F, Jannesar R. Effects of hydrophilic extract of Nasturtium officinale on prevention of ethylene glycol induced renal stone in male Wistar rats. J Nephropathol. 2016;5(4):123-127. DOI: 10.15171/jnp.2016.23

Stamatelou K, Goldfarb DS. Epidemiology of kidney stones. Healthcare (Basel). 2023 Feb 2;11(3):424. DOI: 10.3390/healthcare11030424.

Patel N, Brown RD, Sarkissian C, De S, Monga M. Quality of life and urolithiasis: the patient-reported outcomes measurement information system (PROMIS). Int Braz J Urol. 2017 Sep-Oct;43(5):880-886. DOI: 10.1590/S1677-5538.IBJU.2016.0649.

Nojaba L, Guzman N. Nephrolithiasis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559227/

European Association of Urology. EAU guidelines on urolithiasis. European Association of Urology, London, UK, 2018.

Febriana LG, Sumiwi SA, Levita J. A review on the pharmacotherapy and case studies of hypercalciuria and hyperoxaluria. J Appl Pharm Sci. 2022;12(04):026–036. DOI: 10.7324/JAPS.2022.120403

Wabner CL, Pak CY. Effect of orange juice consumption on urinary stone risk factors. J Urol. 1993;149(6):1405-8. DOI: 10.1016/s0022-5347(17)36401-7.

Kirdpon S, Nakorn SN, Kirdpon W. Changes in urinary chemical composition in healthy volunteers after consuming roselle (Hibiscus sabdariffa Linn.) juice. J Med Assoc Thai. 1994;77:314–321.

Howell AB, Vorsa N, Der Marderosian A, Foo LY. Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N Engl J Med. 1998;339:1085–1086.

Premgamone A, Sriboonlue P, Disatapornjaroen W, Maskasem S, Sinsupan N, Apinives C. A long-term study on the efficacy of a herbal plant, Orthosiphon grandiflorus, and sodium potassium citrate in renal calculi treatment. Southeast Asian J Trop Med Public Health. 2001;32:654–660.

Kessler T, Jansen B, Hesse A. Effect of blackcurrant-, cranberry- and plum juice consumption on risk factors associated with kidney stone formation. Eur J Clin Nutr. 2002;56:1020–1023.

Hönow R, Laube N, Schneider A, Kessler T, Hesse A. Influence of grapefruit-, orange- and apple-juice consumption on urinary variables and risk of crystallization. Br J Nutr. 2003;90(2):295-300. DOI: 10.1079/bjn2003897.

McHarg T, Rodgers A, Charlton K. Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation. BJU Int. 2003;92(7):765-8. doi: 10.1046/j.1464-410x.2003.04472.x.

Gettman MT, Ogan K, Brinkley LJ, Adams-Huet B, Pak CY, Pearle MS. Effect of cranberry juice consumption on urinary stone risk factors. J Urol. 2005;174:590–594.

Odvina CV. Comparative value of orange juice versus lemonade in reducing stone-forming risk. Clin J Am Soc Nephrol. 2006;1(6):1269-74. DOi: 10.2215/CJN.00800306.

Prasongwatana V, Woottisin S, Sriboonlue P, Kukongviriyapan V. Uricosuric effect of Roselle (Hibiscus sabdariffa) in normal and renal-stone former subjects. J Ethnopharmacol. 2008;117:491–495.

Micali S, Sighinolfi MC, Celia A, De Stefani S, Grande M, Cicero AF, Bianchi G. Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study. J Urol. 2006;176:1020–1022.

Stiani SN, Syahidah FM, Fikriani H, Subarnas A, Rusdiana T. Anticalculi activity of apigenin and celery (Apium graveolens L.) extract in rats induced by ethylene glycol-ammonium chloride. J Pharm Bioallied Sci. 2019 Dec;11(Suppl 4):S556-S561. DOI: 10.4103/jpbs.JPBS_202_19

Saremi J, Kargar Jahromi H, Pourahmadi M. Effect of Polygonum aviculare L. on nephrolithiasis induced by ethylene glycol and ammonium chloride in rats. Urol J. 2018;15(3):79-82. DOI: 10.22037/uj.v0i0.3815

Fan QX, Gong SQ, Hong XZ, Feng XM, Zhang FJ. Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models. Eur Rev Med Pharmacol Sci. 2020;24(11):6434-6445. DOI: 10.26355/eurrev_202006_21542

Safari HR, Esmaeili S, Naghizadeh MS, Falahpour M, Malekaneh M, Anani Sarab GR. The effects of aqueous extract of Eryngium campestre on ethylene glycol-induced calcium oxalate kidney stone in rats. Urol J. 2019;16(6):519-524. DOI: 10.22037/uj.v0i0.4287

Yousefi Ghale-Salimi M, Eidi M, Ghaemi N, Khavari-Nejad RA. Inhibitory effects of taraxasterol and aqueous extract of Taraxacum officinale on calcium oxalate crystallization: in vitro study. Ren Fail. 2018;40(1):298-305. DOI:10.1080/0886022X.2018.1455595

Afkari R, Feizabadi MM, Ansari-Moghadam A, Safari T, Bokaeian M. Simultaneous use of oxalate-degrading bacteria and herbal extract to reduce the urinary oxalate in a rat model: A new strategy. Int Braz J Urol. 2019;45(6):1249-1259. DOI: 10.1590/S1677-5538.IBJU.2019.0167

Kaushik J, Tandon S, Bhardwaj R, Kaur T, Singla SK, Kumar J, Tandon C. Delving into the antiurolithiatic potential of Tribulus terrestris extract through -in vivo efficacy and preclinical safety investigations in Wistar rats. Sci Rep. 2019;9(1):15969. DOI: 10.1038/s41598-019-52398-w




DOI: http://dx.doi.org/10.52434/jifb.v15i1.2877

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