Mini Review: Fitokimia, Kemotaksonomi, Dan Sifat Biologis Metabolit Sekunder Dari Tanaman Manggis (Garcinia mangostana L.)

Authors

  • Iqbal Musthapa (SCOPUS: 26325851900)Chemistry Study Program, Indonesian University of Education
  • Mochamad Fajar Islam Ash Shidiqy Universitas Pendidikan Indonesia

DOI:

https://doi.org/10.52434/npcb.v1i1.42540

Keywords:

Garcinia mangostana L, kemotaksonomi, sifat biologis, sitotoksik, tanaman Manggis xanthone

Abstract

Artikel ini membahas aspek fitokimia, kematoksonomi, dan sifat biologis dari senyawa-senyawa yang diisiolasi dari Tanaman Manggis (Garcinia mangostana L.). Dari kajian fitokimia, terdapat 86 senyawa metabolit sekunder telah berhasil diisolasi dan diidentifikasi, yang meliputi xanthone, flavanoid, triterpenoid, benzofenon, bifenil, pirol, dan benzofuran. Kajian kematoksonomi memperlihatkan bahwa senyawa-senyawa pada Tanaman Manggis (Garcinia mangostana L.) juga ditemukan pada tanaman dengan satu famili, yaitu Garcinia. Senyawa yang ditemukan telah dievaluasi aktivitas biologisnya melalui berbagai sistem uji, meliputi sifat sitotoksik, antibakteri dan antijamur, antioksidan, antimalaria, topoisomerasi I dan II, antiinflamasi, HIV-1 protease dan reverse transkriptase. Hasil pengujian senyawa-senyawa metabolit sekunder Manggis memiliki potensi besar sebagai agen antikanker, antioksidan, antibakteri dan antijamur. Pengembangan masih terus dilakukan untuk memperjelas hasil kajian dalam analisis manfaat Tanaman Manggis (Garcinia mangostana L.) sebagai sumber bahan kimia yang memiliki banyak manfaat.

References

Alekshun, M. N., & Levy, S. B. (2006). Commensals upon us. Biochemical Pharmacology, 71(7), 893–900. https://doi.org/10.1016/j.bcp.2005.12.040

Amin, S., Aryanti, R., & Aprilia, A. Y. (2023). Studi In Silico Senyawa yang Terkandung dalam Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Antikanker Payudara. Prosiding Seminar Nasional Diseminasi Penelitian, 3. https://ejurnal.universitas-bth.ac.id/index.php/PSNDPV3/article/view/1162

Anantachoke, N., Tuchinda, P., Kuhakarn, C., Pohmakotr, M., & Reutrakul, V. (2012). Prenylated caged xanthones: Chemistry and biology. Pharmaceutical Biology, 50(1), 78–91. https://doi.org/10.3109/13880209.2011.636176

Azebaze, A. G. B., Meyer, M., Valentin, A., Nguemfo, E. L., Fomum, Z. T., & Nkengfack, A. E. (2006). Prenylated Xanthone Derivatives with Antiplasmodial Activity from Allanblackia monticola Staner L.C. Chemical and Pharmaceutical Bulletin, 54(1), 111–113. https://doi.org/10.1248/cpb.54.111

Chen, S. X., Wan, M., & Loh, B. N. (1996). Active Constituents against HIV-1 Protease from Garcinia mangostana. Planta Medica, 62(4), 381–382. https://doi.org/10.1055/s-2006-957916

Chin, Y. W., Jung, H. A., Chai, H., Keller, W. J., & Kinghorn, A. D. (2008). Xanthones with Quinone Reductase-Inducing Activity from the Fruits of Garcinia mangostana (Mangosteen). Phytochemistry, 69(3), 754–758. https://doi.org/10.1016/j.phytochem.2007.09.023

Cui, J., Hu, W., Cai, Z., Liu, Y., Li, S., Tao, W., & Xiang, H. (2010). New Medicinal Properties of mangostins: Analgesic Activity and Pharmacological Characterization of Active Ingredients from the Fruit Hull of Garcinia mangostana L. Pharmacology Biochemistry and Behavior, 95(2), 166–172. https://doi.org/10.1016/j.pbb.2009.12.021

Farnsworth, N. R., & Bunyapraphatsara, N. (1992). Thai Medicinal Plants Recommended for Primary Health Care System. Mahidol University.

Gopalakrishnan, G., Banumathi, B., & Suresh, G. (1997). Evaluation of the Antifungal Activity of Natural Xanthones from Garcinia mangostana and Their Synthetic Serivatives. Journal of Natural Products, 60(5), 519–524. https://doi.org/10.1021/np970165u

Gutierrez-Orozco, F., & Failla, M. L. (2013). Biological Activities and Bioavailability of mangosteen xanthones: A Critical Review of the Current Evidence. Nutrients, 5(8), 3163–3183. https://doi.org/10.3390/nu5083163

Heyne, K. (1987). Tumbuhan berguna Indonesia III. In Yayasan Sarana Wana Jaya Jakarta. Yayasan Sarana Wana Jaya Jakarta.

Himawan, H. C., Sulastri, L., & Vernando, V. (2018). Penambatan Molekuler Senyawa Xanton pada Kulit Buah Manggis (Garcinia Mangostana L.) dengan Enzim Cox-2 sebagai Kandidat Antikanker Payudara. Jurnal Farmamedika (Pharmamedica Journal), 3(1), 34–42. https://doi.org/10.47219/ath.v3i1.28

Iinuma, M., Tosa, H., Tanaka, T., Asai, F., Kobayashi, Y., Shimano, R., & Miyauchi, K. I. (1996). Antibacterial Activity of Xanthones from Guttiferaeous Plants against methicillin-resistant Staphylococcus aureus. Journal of Pharmacy and Pharmacology, 48(8), 861–865. https://doi.org/10.1111/j.2042-7158.1996.tb03988.x

Jung, H. A., Su, B. N., Keller, W. J., Mehta, R. G., & Kinghorn, A. D. (2006). Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen). Journal of Agricultural and Food Chemistry, 54(6), 2077. https://doi.org/10.1021/jf052649z

Loo, A. E. K., & Huang, D. (2007). Assay-guided Fractionation Study of α-amylase Inhibitors from Garcinia mangostana pericarp. Journal of Agricultural and Food Chemistry, 55(24), 9805-9810. https://doi.org/10.1021/jf071500f

Mahabusarakam, W., Kuaha, K., Wilairat, P., & Taylor, W. C. (2006). Prenylated Xanthones as Potential Antiplasmodial Substances. Planta Medica, 72(10), 912–916. https://doi.org/10.1055/s-2006-947190

Moongkarndi, P., Kosem, N., Kaslungka, S., Luanratana, O., Pongpan, N., & Neungton, N. (2004). Antiproliferation, Antioxidation and Induction of Apoptosis by Garcinia mangostana (mangosteen) on SKBR3 Human Breast Cancer Cell Line. Journal of Ethnopharmacology, 90(1), 90–161. https://doi.org/10.1016/j.jep.2003.09.048

Muhanji, C., & Hunter, R. (2007). Current Developments in the Synthesis and Biological Activity of HIV-1 Double-Drug Inhibitors. Current Medicinal Chemistry, 14(11), 1207–1220. https://doi.org/10.2174/092986707780597952

Mursyidin, D. H., & Maulana, F. N. (2020). Keragaman dan Kekerabatan Genetik Garcinia berdasarkan Kandungan Senyawa Bioaktif dan Aktivitas Biologisnya: Kajian In Silico. Berita Biologi, 19(3A). https://doi.org/10.14203/beritabiologi.v19i3a.3862

Murthy, H. N., Dandin, V. S., Dalawai, D., Park, S. Y., & Paek, K. Y. (2018). Breeding of Garcinia spp. In Advances in Plant Breeding Strategies: Fruits (Vol. 3, pp. 773–809). Springer. https://doi.org/10.1007/978-3-319-91944-7_19

Prasetiawati, R., Permana, B., Soni, D., & Agung, S. N. (2019). Molecular Docking Study of Xanthone Derivative Compounds of Mangosteen Rind (Garcinia mangostana L.) to ER- α ( Estrogen Receptor Alfa) and ER - β ( Estrogen Receptor Beta ) as Anti-Breast Cancer. Jurnal Ilmiah Farmako Bahari, 10(1), 45–52. https://doi.org/https://doi.org/10.52434/jfb.v9i1.642

Putra, S. R. (2011). Manggis Pembasmi Kanker. Diva Press.

Qosim, W. A. (2007). Kulit Buah Manggis Sebagai Antioksidan. Lembaga Pengabdian Masyarakat (LPM) Universitas Padjajaran.

Rahmayanti, F., Suniarti, D. F., Masúd, Z. A., Bachtiar, B. M., Wimardhani, Y. S., & Subita, G. P. (2016). Ethyl Acetate Fraction of garcinia mangostana-linn pericarp extract: Anti - Candida albicans and epithelial cytotoxicity. Asian Journal of Pharmaceutical and Clinical Research, 9(1), 335– 338. https://journals.innovareacademics.in/index.php/ajpcr/article/view/10088

Rassameemasmaung, S., Sirikulsathean, A., Amornchat, C., Hirunrat, K., Rojanapanthu, P., & Gritsanapan, W. (2007). Effects of Herbal Mouthwash Containing the Pericarp Extract of Garcinia mangostana L on Halitosis, Plaque and Papillary Bleeding Index. Journal of the International Academy of Periodontology, 9(1), 19–25. https://pubmed.ncbi.nlm.nih.gov/17274236/

Riscoe, M., Kelly, J. X., & Winter, R. (2005). Xanthones as Antimalarial Agents: Discovery, Mode of Action, and Optimization. Current Medicinal Chemistry, 12(21), 2539–2549. https://doi.org/10.2174/092986705774370709

Ruan, J., Zheng, C., Liu, Y., Qu, L., Yu, H., Han, L., Zhang, Y., & Wang, T. (2017). Chemical and Biological Research on Herbal Medicines Rich in Xanthones. Molecules, 22(10), 1–19. https://doi.org/10.3390/molecules22101698

Sakagami, Y., Iinuma, M., Piyasena, K. G. N. P., & Dharmaratne, H. R. W. (2005). Antibacterial Activity of α-mangostin against Vancomycin Resistant Enterococci (VRE) and Synergism with Antibiotics. Phytomedicine, 12(3), 203–208. https://doi.org/10.1016/j.phymed.2003.09.012

Sampath, P. D., & Vijayaraghavan, K. (2007). Cardioprotective Effect of α-mangostin, a Xanthone Derivative from Mangosteen on Tissue Defense System against Isoproterenol-Induced Myocardial Infarction in Rats. Journal of Biochemical and Molecular Toxicology, 21(6), 336–339. https://doi.org/10.1002/jbt.20199

Shabella, R. (2011). Terapi Kulit Manggis. Galmas.

Sholihah, M., Ahmad, U., & Budiastra, I. W. (2017). Aplikasi Gelombang Ultrasonik Untuk Meningkatkan Rendemen Ekstraksi dan Efektivitas Antioksidan Kulit Manggis. Jurnal Keteknikhan Pertanian, 5(2). https://doi.org/https://doi.org/10.19028/jtep.05.2.%25p

Sinaga, S., Sobir, S., Poerwanto, R., Aswidinnoor, H., & Duryadi, D. (2012). Genetic Diversity and the Relationship Between the Indonesian Mangosteen (Garcinia Mangostana) and the Related Species using Isozyme Markers. Jurnal Natur Indonesia, 13(1), 53–58. https://doi.org/10.31258/jnat.13.1.53-58

Tosa, H., Iinuma, M., Tanaka, T., Nozaki, H., Ikeda, S., Tsutsui, K., Tsutsui, K., Yamada, M., & Fujimori, S. (1997). Inhibitory Activity of Xanthone Derivatives Isolated from Some Guttiferaeous Plants Against DNA Topoisomerases I and II. Chemical and Pharmaceutical Bulletin, 45(2), 418–420. https://doi.org/10.1248/cpb.45.418

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007). Free Radicals and Antioxidants in Normal Physiological Functions and Human Disease. International Journal of Biochemistry and Cell Biology, 39(1), 44–84. https://doi.org/10.1016/j.biocel.2006.07.001

Weecharangsan, W., Opanasopit, P., Ngawhirunpat, T., Rojanarata, T., & Apirakaramwong, A. (2006). Chitosan Lactate as a Nonviral Gene Delivery Vector in COS-1 Cells. AAPS PharmSciTech, 7(3), 74–79. https://doi.org/10.1208/pt070366

Williams, P., Ongsakul, M., Proudfoot, J., Croft, K., & Beilin, L. (1995). Mangostin Inhibits the Oxidative Modification of Human Low Density Lipoprotein. Free Radical Research, 23(2), 175–184. https://doi.org/10.3109/10715769509064030

Yates, P., & Stout, G. H. (1958). The Structure of Mangostin. Journal of the American Chemical Society, 80(7), 1691.

Yoshikawa, M., Harada, E., Miki, A., Tsukamoto, K., Si Qian Liang, Yamahara, J., & Murakami, N. (1994). Antioxidant Constituents from the Fruit Hulls of Mangosteen (Garcinia mangostana L.) Originating in Vietnam. Yakugaku Zasshi, 114(2), 129–133. https://doi.org/10.1248/yakushi1947.114.2_129

Yu, L., Zhao, M., Yang, B., Zhao, Q., & Jiang, Y. (2007). Phenolics from Hull of Garcinia Mangostana Fruit and Their Antioxidant Activities. Food Chemistry, 104(1), 176–181. https://doi.org/10.1016/j.foodchem.2006.11.018

Published

2025-05-31