https://journal.uniga.ac.id/index.php/JFB/issue/feedJurnal Ilmiah Farmako Bahari2024-02-17T11:40:17+08:00Dr. Ria Marianiriariono@gmail.comOpen Journal Systems<p><a href="/index.php/JFB"><img src="/public/site/images/deni/JFB3.png" alt="" /></a></p>https://journal.uniga.ac.id/index.php/JFB/article/view/2544EVALUASI PENGGUNAAN OBAT ARB DAN DIURETIK PADA PASIEN RAWAT INAP DENGAN DIAGNOSIS GAGAL JANTUNG DI RUMAH SAKIT KECAMATAN BALEENDAH PROVINSI JAWA BARAT2024-02-13T14:52:57+08:00Vina Septianivinaseptianiffarmasiunjani@gmail.comEni Margayanivinaseptianiffarmasiunjani@gmail.comLinda P Suhermanvinaseptianiffarmasiunjani@gmail.comMeira Meicareenavinaseptianiffarmasiunjani@gmail.com<p>Gagal jantung adalah kondisi klinis di mana jantung tidak dapat memompa darah yang cukup untuk memenuhi kebutuhan tubuh. Penelitian ini bertujuan untuk mengetahui pola penggunaan obat golongan ARB dan diuretik mengetahui ketepatan terapi gagal jantung golongan ARB dan diuretik serta meliputi parameter tepat indikasi, tepat pemilihan obat, dan tepat dosis pada pasien rawat inap di salah satu Rumah Sakit di Provinsi Jawa Barat tahun 2021 untuk meningkatkan penggunaan obat yang rasional. Penelitian ini merupakan penelitian non eksperimental yang melakukan penelitian deskriptif dan mengumpulkan data dari rekam medis pasien secara retrospektif. Untuk pengambilan sampel, digunakan metode purposive sampling.<em> </em>Data diambil dari sampel yang memenuhi kriteria inklusi kemudian dianalisis baik secara kuantitatif dan kualitatif. Populasi pasien tahun 2021 sebanyak 152 pasien dan yang memenuhi kriteria inklusi sebanyak 48 pasien. Berdasarkan hasil penelitian pada pasien gagal jantung tahun 2021, diperoleh bahwa pasien gagal jantung lebih banyak pada pasien laki- laki sebesar 56,25% dan rentang usia yang lebih banyak pada usia 56-65 tahun sebesar 47,92%. Obat gagal jantung yang paling banyak diresepkan adalah kombinasi 2 obat yaitu Candesartan + Furosemide sebesar 43,5%. Hasil analisis kualitatif penggunaan obat pasien gagal jantung di salah satu Rumah Sakit di Provinsi Jawa Barat tahun 2021 diperoleh bahwa pasien sudah 100% tepat indikasi, 100% tepat pemilihan obat, dan 98% tepat dosis. <strong></strong></p>2024-01-31T16:49:25+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/2790SYNTHESIS OF TETRACYCLINE IMPRINTED POLYMERS WITH METHACRYLIC ACID AS FUNCTIONAL MONOMER IN METHANOL-CHLOROFORM MIXTURE USING BULK AND PRECIPITATION POLYMERIZATION METHOD2024-02-13T15:08:53+08:00Shendi Suryanashendi@fmipa.uniga.ac.idKharisma Devy Shabrinashendi@fmipa.uniga.ac.idDang Sonidang@uniga.ac.id<p>The content of tetracycline residues in poultry meat products can cause antibiotic resistance in humans who consume these products, so it is necessary to develop sensitive analytical techniques to determine the levels of tetracycline residues to assess the safety of these products for consumption. The molecular imprinting technique is a method to produce sorbents with molecular recognition capability of target compounds that can be used to increase the selectivity of solid phase extraction to extract tetracycline residues for further analysis. This study aimed to obtain a sorbent synthesized by molecular imprinting technique to analyze tetracycline in poultry meat products. The stages of the research began with the study of the interaction of functional monomers with template molecules, determining the association constants of functional monomers with template molecules, synthesis of imprinted polymer molecules using bulk and precipitation methods, evaluating the ability and adsorption capacity of the synthesized polymers, assess the selectivity of polymers for analog structures and physical characteristics with FTIR. The research showed that methacrylic acid was the best functional monomer with a binding energy value of -27.3776 kcal/mol. The higher adsorption capacity was achieved by Molecularly Imprinted Polymer (MIP) that was synthesized by precipitation method (MIP2) than the other MIP synthesized by bulk polymerization (MIP1) with a value of 0.8748 mg/g and 0.4077 mg/g, respectively. The analogous compounds' imprinting factor values for each MIP were 1.197 and 1.1272. The polymer synthesized by molecular imprinting technique is selective for extracting and analyzing tetracycline from poultry meat matrix.</p>2024-01-31T16:49:26+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/2918PRODUKSI ASAM LAKTAT OLEH LACTOBACILLUS ACIDOPHILUS DALAM MEDIA FERMENTASI KOMBINASI LIMBAH CAIR TAHU DAN MANGGA (Mangifera indica l.)2024-02-13T14:52:57+08:00Mellova Amirmellova.amir@esaunggul.ac.idNeng Sopiatunnisamellova.amir@esaunggul.ac.idInherni Marti Abnamellova.amir@esaunggul.ac.id<p>Lactic acid is a hydroxycarboxylic organic acid used for various purposes and can be obtained through the fermentation of sugar from various sources. This research aimed to determine the ability of Lactobacillus acidophilus in a combination of tofu and mango waste to produce lactic acid using the fermentation method. Variations in media concentration for the combination of tofu and mango liquid waste are 0%, 25%, 50%, and 100% used with the basic fermentation media. The initial stage is the cultivation of L acidophilus, the growth curve, and then the fermentation process, determining the PH and levels of lactic acid produced using spectrophotometry. The research showed that L. acidophilus, combining tofu and mango liquid waste media, could produce lactic acid. Lactic acid levels in 0% combination media with 100% basic media were 2,040 mg/L, 25% combination media, 75% basic media, 2,081 mg/L, 50% combination media, 50% basic media, 2,316 mg/L, combination media 100 % of 2,440 mg/L. The highest levels of lactic acid were produced using a combination of 100% tofu and mango liquid waste at the 48th hour, amounting to 2,440 mg/L.</p>2024-01-31T16:49:28+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/2671UJI EVALUASI FISIK DAN AKTIVITAS ANTI JAMUR SEDIAAN OVULA EKSTRAK BAWANG PUTIH TERHADAP CANDIDA ALBICANS2024-02-13T14:52:57+08:00Lusi Nurdiantilusinurdianti83@gmail.comAi Gita Aisah Adhanilusinurdianti83@gmail.comTaufik Hidayatlusinurdianti83@gmail.comFajar Setiawanlusinurdianti83@gmail.comAde Yeni Aprillialusinurdianti83@gmail.comLilis Tuslinahlusinurdianti83@gmail.comArdianes Firmansyalusinurdianti83@gmail.com<p>Kandidiasis vulvovagina merupakan penyakit umum di kalangan wanita yang membutuhkan penanganan cepat. Kandidiasis vagina dapat diakibatkan oleh infeksi jamur, terutama <em>Candida albicans</em> menyebabkan gejala seperti gatal-gatal, keputihan, kemerahan vagina, dan ketidaknyamanan saat berhubungan seksual serta buang air kecil. Bawang putih (<em>Allium sativum L.)</em>, khususnya senyawa allicin memiliki potensi sebagai antibakteri dan antijamur. Selain itu, bawang putih juga mengandung saponin dan flavonoid. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak etanol <em>Allium sativum L </em>sebagai antijamur terhadap <em>Candida albicans</em> dan untuk mengembangkan sediaan ovula berbasis gelatin dengan konsentrasi ekstrak 20%, 25%, dan 30%. Pengujian daya hambat ovula ekstrak <em>Allium sativum L</em> dilakukan dengan metode sumuran menggunakan <em>Cylinder cup</em>. Hasil penelitian menunjukkan bahwa ovula ekstrak <em>Allium sativum L </em>dengan konsentrasi 20%, 25%, dan 30% memiliki daya hambat rata-rata masing-masing 6,1±0,290 mm, 8,06±0,750 mm dan 11,33±0,460 mm. Analisis ANOVA dilanjutkan dengan uji <em>Least Significant Difference</em> (LSD) menunjukkan perbedaan signifikan dalam kemampuan ovula menghambat pertumbuhan <em>Candida albicans</em>. Oleh karena itu, disimpulkan bahwa ovula ekstrak <em>Allium sativum L </em>memiliki potensi sebagai antijamur yang efektif.</p>2024-01-31T16:49:28+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/3109PENINGKATAN KELARUTAN DAN LAJU DISOLUSI GLIKLAZID DENGAN POLIMER SILIKA MIKROSFER (SM)2024-02-13T14:52:57+08:00Aris Purwantoarispurwanto@umbjm.ac.idMustika Muthaharaharispurwanto@umbjm.ac.idAndika Andikaarispurwanto@umbjm.ac.id<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Cara yang dilakukan dengan menambahkan koformer dan </span><span>Mikrosfer Silika Mesopore </span><span>(MSM) yang dihasilkan dari sintesis sebelumnya. Menggunakan perbandingan 4 mmol gliklazid : 4 mmol koformer dilarutkan kedalam metanol untuk menghasilkan bentuk kokristal, perbandingan yang sama dengan penambahan silika mikrosfer sebanyak 800 mg untuk menghasilkan </span><span>nano- confined coamorphous </span><span>(NCA), dengan cara yang sama MSM dimasukkan kedalam gliklazid untuk mendapatkan gliklazid amorf. Karakterisasi berupa uji kelarutan menggunakan cara </span><span>Higuchi and Connor, </span><span>uji disolusi, FTIR dan DSC. Hasil kelarutan kokristal mengalami kenaikan 2,5 kali, gliklazid amorf mengalami kenaikan 1,3 kali dan NCA sistem naik 1,6 kali lipat dari gliklazid murni. Data hasil uji disolusi pada menit (60) gliklazid murni hanya terlarut 46,83%, bentuk kokristal 69,69%, berbeda pada gliklazid amorf yang sudah mencapai 98,15% dan sistem NCA mencapai 98,64%. Karakterisasi menggunakan FTIR terlihat pergeseran puncak serapan setelah gliklazid mengalami perubahan bentuk kokristal, amorf dan koamorf sedangkan hasil karakterisasi DSC penurunan intensitas pola difraksi mengalai perubahan setelah dilakukan proses dispersi. </span></p></div></div></div>2024-01-31T16:49:29+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/3207FUCOIDAN NANOENCAPSULATION FROM BROWN ALGAE (Sargassum polycystum) AS A POTENTIAL MARINE IMMUNOMODULATORY AGENT2024-02-13T14:52:57+08:00Ungsari Rizki Eka Purwantoendangdiyahikasari@gmail.comEndang Diyah Ikasariendangdiyahikasari@gmail.comI Kadek Bagianaendangdiyahikasari@gmail.comLia Kusmitaendangdiyahikasari@gmail.comNi Nyoman Ayu Indah Trisnayanthiendangdiyahikasari@gmail.comI Wayan Mudiantaendangdiyahikasari@gmail.comRahmadi Prasetijoendangdiyahikasari@gmail.com<p>The quest for better and more effective treatments has encouraged the search for therapies derived from natural sources to obtain effective immune therapy, considering that several pandemics have arisen caused by viruses. Developing fucoidan from brown algae in drug encapsulation as an immunomodulator could be more promising. This study aimed to produce nanoencapsulation loaded with fucoidan-purified extract from brown algae and to evaluate the influence of nanoencapsulation formulation on the immunomodulatory activity of fucoidan. Fucoidan was obtained from brown algae and extracted by hot aqueous, followed by ethanol purification. Nanoencapsulation of fucoidan purified extract was prepared using the ionic gelation method. The carbon clearance method was carried out for the immunomodulatory activity test of the nanoencapsulation of fucoidan purified extract. Nanoencapsulation of fucoidan purified extract with the optimum composition of maltodextrin 9.9% and S-TPP 0.1% (1:5) resulted in particle size of 715.4 nm, zeta potential -0.1 mV, pH 7.54, transmittance 97.54%+0.08, and entrapment efficiency 89.94%+0.17. The carbon clearance test showed that the nanoencapsulation of fucoidan was a strong immunostimulant with a phagocytosis index of 1.65. The development of nanoencapsulation could increase the phagocytosis index of fucoidan purified extracts from brown algae. Further molecular studies are needed to demonstrate the molecular activity of this preparation as an immunomodulator.</p>2024-01-31T16:49:30+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/3243HEALTH RELATED QUALITY OF LIFE (HRQoL) IN CHRONIC KIDNEY FAILURE PATIENTS AT ARIFIN AHMAD REGIONAL GENERAL HOSPITAL RIAU PROVINCE2024-02-13T14:52:57+08:00Rickha Octaviarickhaoctavia@stifar-riau.ac.idSeftika Sariseftikasari@stifar-riau.ac.idFitriatun Nisa'fitriatunnisa'@stifar-riau.ac.id<p>After tuberculosis, the illness with the highest death rate is chronic kidney failure. Renal function declines in patients with chronic kidney failure until, eventually, they are unable to filter and eliminate the body's electrolytes at all. Metrics about quality of life are necessary because the patient's health will suffer if medical therapy fails. This research aims to determine the description of health-related quality of life (HRQoL) in chronic kidney failure patients at the Arifin Achmad Regional General Hospital, Riau Province. The samples used in this study were chronic kidney failure patients who underwent treatment at the Arifin Achmad Regional General Hospital, Riau Province, in the period January-December 2022 and met the inclusion and exclusion criteria. This study is observational and descriptive. Non-probability sampling was employed to select 74 participants for the study. Based on the results of research that has been carried out regarding the description of health-related quality of life (HRQoL) in patients with chronic kidney failure at the Arifin Achmad Regional General Hospital, Riau Province, it was found that chronic kidney failure has an impact on the quality of life in health with an average utility value of EQ-5D -5L and VAS namely 0.6235 and 0.7177. Anxiety or depression (40.5%) and pain or discomfort (52.7%) were the most commonly reported health issues.</p>2024-01-31T16:49:30+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/3259ANTI-ACNE FACIAL WASH FORMULATION FROM RED BETEL LEAF EXTRACT (PIPER CROCATUM RUIZ & PAV)2024-02-13T15:00:07+08:00Siti Hindunsitihindun@uniga.ac.idAmirah Mohd Gazzalisitihindun@uniga.ac.idAji Najihudinsitihindun@uniga.ac.idSiva Hamdanisitihindun@uniga.ac.idNopi Rantikasitihindun@uniga.ac.idWinanda Nur Azizahsitihindun@uniga.ac.id<p>Acne can be caused by dust, sweat, and dirt that stick to the skin, forming blackheads. When blackheads become infected with bacteria, inflammation can occur. Therefore, it is essential to maintain good skin hygiene. One way to do this is by using natural ingredients with antibacterial properties. Red betel leaf is known to have antibacterial activity. This study aims to create a facial wash using red betel leaf extract that exhibits antibacterial properties against Propionibacterium acnes. The red betel leaf was extracted using the maceration method. Antibacterial testing was conducted against Propionibacterium acnes bacteria using the suitable diffusion method with a combination of red betel leaf extract at 10%, 15%, and 20%. The study found that facial wash products containing extract concentrations of 10%, 15%, and 20% demonstrated good physical stability, meeting the requirements of SNI-19-4380-1996 for pH, viscosity, specific gravity, and foam height. Additionally, the products showed potent antibacterial activity against Propionibacterium acnes bacteria, with inhibition zones of 29.0 mm, 32.6 mm, and 35.3 mm for the 10%, 15%, and 20% concentrations, respectively.</p>2024-01-31T16:49:31+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/3461COMPARISON OF ABTS (2,2-AZINOBIS(3-ETHYLBENZOTHIAZOLINE)-6-SULFONIC ACID) AND DPPH (1,1-DIPHENYL-2-PICRYLHYDRAZYL) ASSAYS TO MEASURE THE ANTIOXIDANT ACTIVITY OF ETANOL EXTRACT OF RED ALGA (Gelidium sp)2024-02-17T11:40:17+08:00Isye Martianiisye.martiani66@gmail.comArdi Rustamsyahardi@uniga.ac.idTien Ellita Endah Puspitasariardi@uniga.ac.idDani Sujanadani.sujana87@gmail.com<p>Seaweeds have an ecological function as primary producers in marine waters. It also has an important economic value as a producer of hydrocolloids (alginate, agar, and carrageenan) used in various food and pharmaceutical industries. This study aims to determine the antioxidant activity of red algae <em>(Gelidium sp).</em> Extraction was done using the maceration method using 96% ethanol and concentrated by rotary evaporation. The antioxidant activity of the extract was tested using ABTS and DPPH methods. Antioxidant activity was seen from the IC<sub>50</sub>. The results showed that IC<sub>50</sub> from ethanol extract of red algae <em>(Gelidium sp)</em> with the DPPH method is 3,9154 ppm. Then, using the ABTS method, IC<sub>50</sub> from ethanol extract of red algae <em>(Gelidium sp)</em> is 9,1178 ppm. This result shows that the ethanol extract from red algae <em>(Gelidium sp)</em> has very strong antioxidant activity (<50 ppm).</p>2024-01-31T00:00:00+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Baharihttps://journal.uniga.ac.id/index.php/JFB/article/view/2877REVIEW OF THE PHYTOTHERAPY FOR NEPHROLITHIASIS2024-02-13T14:52:58+08:00Hanna Salwa Ridwanhanna20006@mail.unpad.ac.idSandra Megantaras.megantara@unpad.ac.idJutti Levitajutti.levita@unpad.ac.id<p>Nephrolithiasis (kidney stone) cases have a prevalence ranging from 1% to 13%. The disease not only hampers kidney function but also elevates the risk of chronic kidney diseases. The pathophysiology of nephrolithiasis is closely linked to elevated concentrations of calcium, oxalate, and/or uric acid in the urine. Pharmacotherapy to manage nephrolithiasis includes thiazide diuretics, allopurinol, citrate supplements, and alpha-blockers that have been prescribed to relieve symptoms. In addition, there is growing interest in exploring the potential of phytotherapy. This review aims to identify suitable phytotherapy approaches by examining relevant articles on nephrolithiasis. The research methodology involved searching PubMed articles using the keywords of (("Plant Extracts") AND ("Nephrolithiasis")) OR ("Ureterolithiasis"). The articles obtained from the initial search were n =123. 2 authors screened articles for their eligibility. The inclusion criteria were limited to articles written in English, topics related to nephrolithiasis and not other kidney diseases, the botanical names of the plants and the method of extraction are clearly described, complete studies with clear descriptions regarding the methods and results, not synthetic drugs, and not involving medical instruments or laser to remove the stones. Articles included in the review were n = 17. Water and hydro-alcohol were the solvents used to extract the plants. Twenty-two plants have confirmed their anti-nephrolithiasis activity, and nine articles described the assay by <em>in vivo</em> study, two by <em>in vitro</em> study, three by both <em>in vitro</em> and <em>in vivo</em> study, and only one article mentioned a study in humans by a randomized-control trial on a mixture of herbs. It is concluded that <em>Rhizoma alismatis, Poria cocos, Polyporus umbellatus, Atractylodis macrocephalae</em>, and <em>Cinnamomi Cassiae</em> prepared as a mixture in the Wu-Ling-San formula have a potential therapeutic effect on nephrolithiasis, as this formula has been studied in humans. <strong><em></em></strong></p>2024-01-31T16:49:31+08:00Copyright (c) 2024 Jurnal Ilmiah Farmako Bahari